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IRAK4-IN-7

SKU: orb1301860

Description

IRAK4-IN-7 (CA-4948) is a potent and selective inhibitor of IRAK4 kinase. It demonstrates in vivo efficacy by reducing cytokine release in TLR4-driven models, supporting its use in research on autoimmune diseases and hematologic cancers.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number1801343-74-7
MW417.42
Purity99.60% (May vary between batches)
FormulaC21H19N7O3
SMILESNc1ccc(cn1)-c1cccc(n1)C(=O)Nc1cnc2nc(oc2c1)N1CCOCC1
TargetIRAK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.4 mM);DMSO:13.89 mg/mL (33.28 mM)

Bioactivity

In Vivo
CA-4948 has antitumor activity in ABC-type diffuse large B cell lymphoma patient-derived xenograft (PDX) mouse models.
In Vitro
CA-4948 was previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models using cell lines OCI-LY3 and OCI-LY10.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

lymphoma, IRAK4IN7, IRAK-4-IN-7, IRAK4-IN-7, IRAK4 IN 7, IRAK-4, IRAK4, IRAK, Interleukin-1 receptor associated kinase, IL-1R associated kinase, inhibit, non-Hodgkin, Inhibitor, large B cell lymphoma, diffuse, DLBCL, CA 4948, CA4948, CA-4948, ABC-type

Similar Products

  • CA-4948 [orb1225891]

    >98% (HPLC)

    1801343-74-7

    417.429

    C21H19N7O3

    1 g, 500 mg, 200 mg, 50 mg, 100 mg, 5 mg, 10 mg, 2 mg, 25 mg
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Key Properties

No computed properties available.

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Protocol Information

IRAK4-IN-7 (orb1301860)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 170.00
25 mg
$ 270.00
50 mg
$ 420.00
100 mg
$ 600.00
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