Carbobenzoxyphenylalanine

SKU: orb1306641

Description

Carbobenzoxyphenylalanine (NSC-402059) is a synthetic inhibitor of the metalloprotease thermolysin. It is utilized in biochemical research to study protease function and inhibition, with applications in enzymology and microbial research involving in vitro experimental models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1161-13-3
MW	299.32
Purity	99.71% (May vary between batches)
Formula	C₁₇H₁₇NO₄
SMILES	OC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
Target	Others,Amino Acids and Derivatives
Solubility	DMSO:60 mg/mL (200.45 mM)

Bioactivity

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In Vitro

The protease can be inhibited by the serine specific reagents phenylmethanesulfonyl fluoride and diisopropyl fluorophosphate and the alkylating reagent, carbobenzoxyphenylalanine chloromethyl ketone, in the presence of organic solvents at 1 mM concentration. The inhibitions of chromatin-bound protease in rat liver by these compounds are irreversible. On the other hand, carbobenzoxyphenylalanine and p-nitrophenyl acetate were shown to be reversible inhibitors of rat liver chromatin-bound protease.

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, NSC402059, NSC-402059, NSC 402059, inhibit, Carbobenzoxy-L-phenylalanine, Carbobenzoxyphenylalanine, thermolysin

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Compound Identifiers

PubChem CID

70878 ↗

Key Properties

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No computed properties available.

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