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Carmofur

SKU: orb1224457

Description

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal Y. Carmofur has been known to induce leukoencephalopathy.

Images & Validation

Key Properties

CAS Number61422-45-5
MW257.27
Purity>98% (HPLC)
FormulaC11H16FN3O3
SMILESO=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
TargetDNA/RNA Synthesis
SolubilityEthanol: 10 mg/mL (38.87 mM); DMSO: 52 mg/mL (202.13 mM)

Bioactivity

In Vivo
Animal model: Male C57BL/6J mice model of LPS-induced ALI. Dosage: 3 mg/kg, 10 mg/kg. Administration: Oral gavage (p.o.), single dose. After LPS treatment (5 mg/kg; Tracheal perfusion, single dose). Result: Significantly inhibited MPO activity, which is a marker of neutrophil abundance. Alleviated alveolar edema and inhibited neutrophil accumulation.
In Vitro
Real Time qPCR Cell line: Raw264.7 Concentration: 10 μM. After LPS treatment (500 ng/mL; 72 h) Incubation time: 30 min. Result: Effectively reduced the mRNA expression of pro-inflammatory cytokines such as IL-1β, IL-6, iNOS, TNF-α. Western blot analysis. Cell line: Raw264.7 Concentration: 1 μM, 3 μM, 10 μM. After LPS treatment (500 ng/mL; 72 h) Incubation time: 30 min. Result: Down-regulated the expression levels of p-p65 and p-κbα proteins in a dose-dependent manner, blocking the nuclear translocation of p65.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HCFU

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Carmofur (orb1224457)

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Available Sizes

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500 mg
50 mg
$ 70.00
100 mg
$ 90.00
200 mg
$ 100.00