Carmofur

SKU: orb1309038

Description

Carmofur (HCFU) is a potent acid ceramidase inhibitor investigated for breast and colorectal cancer. Research applications include in vitro studies of ceramide metabolism and in vivo models exploring its antitumor effects and associated leukoencephalopathy.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Neuroscience

Images & Validation

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Key Properties

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CAS Number	61422-45-5
MW	257.26
Purity	99.98% (May vary between batches)
Formula	C₁₁H₁₆FN₃O₃
SMILES	CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O
Target	Virus Protease,FAAH,DNA/RNA Synthesis,SARS-CoV,Nucleoside Antimetabolite/Analog,Glutathione Peroxidase
Solubility	DMSO:250 mg/mL (971.78 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:10 mg/mL (38.87 mM)

Bioactivity

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Target IC50

AC:29 ± 5 nM

In Vitro

Carmofur is one of the masked compounds of 5-FU, which was modified for more potent antineoplastic activity and less toxicity. Carmofur is converted in vivo into 5-FU directly or via intermetabolites, such as 1-(carboxypentylcarbamoyl)-5-fluorouracil and/or 1-(carboxypropylcarbomoyl)-5-fluorouraci. Carmofur and its metabolites gradually accumulate in the brain during continuous administration and are removed very slowly. Carmofur has potent neurotoxicity which can produce severe leucoencephalopathy resembling methotrexate leucoencephalopathy both clinically and on brain CT, together with a cerebellar syndrome similar to that following 5-FU neurotoxicity.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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derivative, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, Analog, antineoplastic, Carmofur, 5-fluorouracil, inhibit, Mpro, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, Nucleoside Antimetabolite, HCFU, Inhibitor, VirusProtease, Virus Protease, protease, RNASynthesis, RNA Synthesis, SARSCoV, SARS-CoV, SARS coronavirus

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Compound Identifiers

PubChem CID

2577 ↗

Key Properties

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No computed properties available.

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Purity:	>98% (HPLC)
CAS Number:	61422-45-5
MW:	257.27
Formula:	C₁₁H₁₆FN₃O₃

Carmofur

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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