Castanospermine

SKU: orb1217638

Description

Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

Images & Validation

−

Key Properties

−

CAS Number	79831-76-8
MW	189.21
Purity	>98% (HPLC)
Formula	C₈H₁₅NO₄
SMILES	O[C@@H](CC1)[C@H]([C@H]([C@@H]2O)O)N1C[C@@H]2O
Target	Glucokinase
Solubility	Water: 32 mg/mL (169.12 mM)

Bioactivity

−

In Vivo

Animal model: A/J mice model. Dosage: 10, 50, 250 mg/kg. Administration: i.p. Result: Decreased secretion and virus infectivity, and increased survival rate of mice infected with DEN virus. Animal model: Acute pancreatitis (AP) rat model. Dosage: 10, 50, 100, 200, 500 mg/kg. Administration: i.p. Result: The extent and severity of the pancreatic injury were significantly decreased. Decreased the interleukin production in serum and NF-kB activation. Increased the level of TNF-a, ICAM-1 and VCAM-1.

In Vitro

Castanospermine (0.01-1000 μM, 48 h) inhibits the production of DEN infectious virus in a dose-dependent manner and slows the electrophoretic mobility of DEN prM (a glycosylated structural protein) in BGK-21 cells. RT-PCR Cell line: BHK-21. Concentration: 100, 500 μM. Incubation time: 48 h. Result: Reduced marker gene expression or propagation of WNV or DEN replicons modestly by up to 20 to 40%, respectively. Had small effects on the secretion of infectious WNV or viral particles containing WNV RNA but decreased the amount of DEN viral RNA and infectious virus.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

1,6,7,8-Tetrahydroxyoctahydroindolizine | (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

Glucokinase

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols