Castanospermine

SKU: orb1296063

Description

Castanospermine is a natural indolizidine alkaloid that acts as a potent inhibitor of α- and β-glucosidases, with notable activity against glucosidase I. It is widely used in biochemical research to study glycoprotein processing, viral entry mechanisms, and metabolic disorders in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	79831-76-8
MW	189.21
Purity	99.93%
Formula	C₈H₁₅NO₄
SMILES	OC1CCN2CC(O)C(O)C(O)C12
Target	glycosidase,Glucosidase
Solubility	H2O:32 mg/mL (169.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.57 mM);DMSO:140 mg/mL (739.92 mM)

Bioactivity

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In Vivo	Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice . Read more...
In Vitro	Castanospermine is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro .

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Castanospermine, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine, 1,6,7,8-Tetrahydroxyoctahydroindolizine, inhibit, Inhibitor, Glucosidase, α-glucosidase, β-glucosidase

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Compound Identifiers

PubChem CID

2592 ↗

Key Properties

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No computed properties available.

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