Catalpol

SKU: orb1225547

Description

Catalpol, an iridoid glycoside, has neuroprotective, anti-inflammatory, and anti-hepatitis virus effects.(In Vitro):Catalpol (0.1 μg/mL; for 3 days) can induce neuronal differentiation in PC12 cells through activation of the intracellular signal transduction pathway, and promote neurite length.(In Vivo):Catalpol (25-100 mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities.

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Key Properties

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CAS Number	2415-24-9
MW	362.33
Purity	>98% (HPLC)
Formula	C₁₅H₂₂O₁₀
SMILES	[H][C@]1([C@H](O)[C@@]2([H])[C@]3(CO)O2)[C@]3([H])[C@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)OC=C1
Target	Others
Solubility	DMSO: 10 mM

Bioactivity

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In Vivo

Catalpol (25-100 mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities. Animal model: C57BL/6 mice treated with renal ischemia/reperfusion surgery. Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg. Administration: Intraperitoneal injection; once. Result: Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Catalpinoside | 7,8-epoxy Aucubin

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Catalpol (orb1225547)

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Purity:	98.0%（HPLC）
CAS Number:	2415-24-9

Purity:	99.89% (May vary between batches)
CAS Number:	2415-24-9
MW:	362.33
Formula:	C₁₅H₂₂O₁₀

CAS Number:	39012-20-9
MW:	512.46
Formula:	C₂₃H₂₈O₁₃

Purity:	99.92% (May vary between batches)
CAS Number:	211567-04-3
MW:	508.47
Formula:	C₂₄H₂₈O₁₂

CAS Number:	834155-36-1
MW:	552.5
Formula:	C₂₆H₃₂O₁₃

Catalpol

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Catalpol (orb1225547)

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