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Ceefourin 1

SKU: orb1298798

Description

Ceefourin 1 is a potent and selective small-molecule inhibitor of Multidrug Resistance Protein 4 (MRP4/ABCC4). It is a valuable research tool for investigating MRP4-mediated transport in vitro and exploring its role in cellular efflux, chemoresistance, and nucleotide signaling in relevant research models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number315702-40-0
MW294.42
Purity99.15% (May vary between batches)
FormulaC11H10N4S3
SMILESCn1c(CSc2nc3ccccc3s2)n[nH]c1=S
TargetOthers,MRP,P-gp
SolubilityDMSO:11 mg/mL (37.36 mM)

Bioactivity

In Vitro
Ceefourin 1 and Ceefourin 2, that inhibit transport of a broad range of MRP4 substrates, yet are highly selective for MRP4 over other ABC transporters, including P-glycoprotein (P-gp), ABCG2 (Breast Cancer Resistance Protein; BCRP) and MRP1 (multidrug resistance protein 1; ABCC1). Both compounds are more potent MRP4 inhibitors in cellular assays than the most widely used inhibitor, MK-571, requiring lower concentrations to effect a comparable level of inhibition. Furthermore, Ceefourin 1 and Ceefourin 2 have low cellular toxicity, and high microsomal and acid stability.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

protein, resistance, P-gp, P-glycoprotein, neuroblastoma, multidrug, inhibit, MRP1, MRP4, Inhibitor, HEK293, efflux, chemosensitizers, Ceefourin1, Ceefourin-1, Ceefourin 1, D-luciferin, BCRP, ABC, ABCC1, ABCG2

Similar Products

  • Ceefourin 1 [orb1219913]

    >98% (HPLC)

    315702-40-0

    294.42

    C11H10N4S3

    1 g, 500 mg, 200 mg, 2 mg, 5 mg, 25 mg, 50 mg, 100 mg, 10 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Ceefourin 1 (orb1298798)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 120.00
1 ml x 10 mM (in DMSO)
$ 130.00
10 mg
$ 170.00
25 mg
$ 310.00
50 mg
$ 450.00
100 mg
$ 620.00
200 mg
$ 870.00
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