Cefazolin sodium salt

SKU: orb1225458

Description

Cefazolin sodium is a first-generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections.(In Vitro):Cefazolin sodium (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide.Cefazolin sodium (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation.Cefazolin sodium (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation.(In Vivo):Cefazolin sodium (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery.

Images & Validation

−

Key Properties

−

CAS Number	27164-46-1
MW	476.48
Purity	>98% (HPLC)
Formula	C₁₄H₁₃N₈NaO₄S₃
SMILES	CC1=NN=C(S1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)[O-].[Na+]
Target	Antibacterial
Solubility	DMSO: 10 mM

Bioactivity

−

In Vivo

Cefazolin sodium (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery. Animal model: 6-to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy. Dosage: 300-500 mg/kg. Administration: Subcutaneous injection; 300-500 mg/kg; once daily; 5 days. Result: Attenuated learning and memory dysfunction induced by the surgery.

In Vitro

Cefazolin sodium (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide. Cefazolin sodium (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation. Cefazolin sodium (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation. Cell Viability Assay Cell line: C8-B4 cells. Concentration: 0, 50, 100, 150, 200, 250, or 300 μg/ml. Incubation time: 6 or 24 hours. Result: Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml. Cell Proliferation Assay Cell line: PBMC, and TF-1 cells. Concentration: 0, 100, 200, and 400 μM. Incubation time: 72 hours. Result: Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc. Cell Viability Assay Cell line: PBMC, NK-92, and TF-1 cells. Concentration: 0, 100, 200, and 400 μM. Incubation time: 30 min. Result: Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γc receptors.

Storage & Handling

−

Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

−

NSC 291561 | SKF 41558

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Quick Database Links

Gene Symbol

Antibacterial

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols