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CXCR Antibody

SKU: orb3131538

Description

VX5 is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. It significantly inhibits human CXCL13-mediated CXCR5 internalization and blocks the CXCL13-dependent chemotaxis and migration of both human and mouse B cells (with EC50 values of 105 nM for human tonsil cells and 253 nM for pre-B-697-hCXCR5 cells). VX5 is applicable in the study of autoimmune diseases such as multiple sclerosis and arthritis, as well as cancers like gastric lymphoma and colon cancer.

Images & Validation

Key Properties

Antibody TypeInhibitor Antibody
ClonalityMonoclonal
TargetCXCR
ConjugationUnconjugated

Storage & Handling

StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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CXCR Antibody (orb3131538)

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