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Dexpramipexole

SKU: orb1679027

Description

Dexpramipexole, the (R)-enantiomer of pramipexole, is a mitochondrial protectant that sustains cellular energy production and mitigates ischemia/reperfusion injury by enhancing mitophagy. It has been investigated in preclinical models for conditions like amyotrophic lateral sclerosis (ALS) and cardiac injury, showing potential in both in vitro and in vivo studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number104632-28-2
MW211.33
Purity99.78% (May vary between batches)
FormulaC10H17N3S
SMILESNC1=NC2=C(C[C@H](NCCC)CC2)S1
TargetDopamine Receptor
SolubilityDMSO:8 mg/mL (37.86 mM)

Bioactivity

In Vitro
Dexpramipexole is neuroprotective and has been used in research studies for the treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits activation of apoptotic pathways, and improves cell survival in response to a variety of neurotoxins and beta-amyloid neurotoxicity. Dexpramipexole is much less active than dopamine agonists of the S-(-) isomer.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

KNS 760704, Dexpramipexole, Dopamine Receptor, Dopamine, DopamineReceptor, Pramipexole, R-Pramipexole

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 530.00
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