Diclofensine hydrochloride

SKU: orb1299543

Description

Diclofensine hydrochloride (Ro 8-4650 hydrochloride) is a novel antidepressant compound for research use. It functions as a monoamine reuptake inhibitor, enabling in vitro and in vivo studies on neurotransmission and peripheral adrenergic mechanisms.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	34041-84-4
MW	358.69
Purity	99.93% (May vary between batches)
Formula	C₁₇H₁₈Cl₃NO
SMILES	Cl.COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1
Target	Dopamine Receptor
Solubility	H2O:52 mg/mL (144.97 mM)

Bioactivity

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In Vitro

The action of diclofensine on peripheral neuronal adrenergic function was studied through tests of the blood pressure response to NE, tyramine, and phenylephrine (PE). The blood pressure response to NE was enhanced and that to tyramine was decreased by diclofensine, as a result of its inhibitive action on peripheral neuronal amine uptake. PE sensitivity was also enhanced by diclofensine as well as after a single dose of desmethylimipramine (DMI). In contrast to the common opinion that PE does not interact with the neuronal uptake mechanism, the increase in PE-induced blood pressure response after diclofensine and DMI suggests that PE, a nonbiogenic amine, does indeed enter into the peripheral adrenergic neuron.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SLC6A3, Ro 8-4650, Ro 8-4650 Hydrochloride, Ro 8-4650 hydrochloride, DAT, DopamineReceptor, Dopamine Transporter, Dopamine Receptor, Diclofensine, Diclofensine hydrochloride, Diclofensine Hydrochloride, inhibit, Inhibitor

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Compound Identifiers

PubChem CID

157489 ↗

Key Properties

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No computed properties available.

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