Diclofensine

SKU: orb1685506

Description

Diclofensine (Ro 8-4650) and dAURK-4 hydrochloride are potent triple monoamine reuptake inhibitors, effectively blocking dopamine, norepinephrine, and serotonin transporters. These compounds are valuable research tools for studying neurotransmitter systems in neuropharmacology, with applications in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	67165-56-4
MW	322.23
Purity	98.13% (May vary between batches)
Formula	C₁₇H₁₇Cl₂NO
SMILES	COc1ccc2C(CN(C)Cc2c1)c1ccc(Cl)c(Cl)c1
Target	5-HT Receptor,Dopamine Receptor,Monoamine Transporter

Bioactivity

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In Vivo

A controlled trial with diclofensine, a new psychoactive drug, in the treatment of depression.

Animal Research

In a controlled study, out-patients suffering from moderate to severe depression were treated with the objective of assessing the new drug's therapeutically effective dose range. Maprotiline was used as a reference drug: fourteen patients were assigned to receive diclofensine and thirteen to receive maprotiline in a double-blind design. Depending on tolerance and efficacy, they were treated for periods ranging from 5 to 150 days. Doses were titrated to the optimum.

Storage & Handling

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Storage	keep away from direct sunlight,store at low temperature \| Pure form: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DAT, Diclofensine, DopamineReceptor, Dopamine Transporter, Dopamine, Dopamine Receptor, 5HTReceptor, 5-HT, 5HT Receptor, MonoamineTransporter, Monoamine transporter, Monoamine Transporter, Neuroscience, SLC6A3, Ro 8-4650

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Compound Identifiers

PubChem CID

68871 ↗

Key Properties

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No computed properties available.

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Diclofensine (orb1685506)

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Purity:	99.93% (May vary between batches)
CAS Number:	34041-84-4
MW:	358.69
Formula:	C₁₇H₁₈Cl₃NO

Purity:	>98% (HPLC)
CAS Number:	67165-56-4
MW:	322.2
Formula:	C₁₇H₁₇Cl₂NO

Diclofensine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Key Properties

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