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EC5026

SKU: orb1309721

Description

EC5026 (BPN-19186) is a research compound that may alleviate pain through the stabilization of endogenous analgesic and anti-inflammatory pathways. It is utilized in preclinical in vitro and in vivo studies to investigate mechanisms of pain modulation and inflammatory resolution.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1809885-32-2
MW405.39
Purity96.6%
FormulaC18H23F4N3O3
SMILESCC[C@H](C)C(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)c(F)c1
TargetEpoxide Hydrolase
SolubilityDMSO:250 mg/mL (616.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.33 mM)

Bioactivity

In Vivo
EC5026 (BPN-19186) is a first-in-class, small molecule that potently inhibits soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of membrane fatty acids. Inhibition of sEH treats pain by stabilizing natural analgesic and anti-inflammatory mediators. sEH inhibitors developed by EicOsis have already shown efficacy for treating pain with no apparent adverse or addictive effects in laboratory animals and relieving naturally occurring pain in dogs, cats and horses.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anti-inflammatory, analgesic, BPN 19186, BPN19186, BPN-19186, pain, inhibit, mediators, Inhibitor, Hydrolase, EC 5026, EC-5026, EC5026, Epoxide, Epoxide Hydrolase, EpoxideHydrolase, Soluble, sEH

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Key Properties

No computed properties available.

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Protocol Information

EC5026 (orb1309721)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 90.00
25 mg
$ 120.00
50 mg
$ 180.00
100 mg
$ 240.00
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