Escin

SKU: orb1310765

Description

Escin (Aescin) is a natural triterpene saponin isolated from horse chestnut (Aesculus hippocastanum) seeds, biosynthesized from precursors like protoaescigenin. It is widely used in pharmacological research for its anti-inflammatory and venotonic properties, studied in both in vitro and in vivo models of edema and vascular permeability.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	6805-41-0
MW	1131.27
Purity	88.51% (May vary between batches)
Formula	C₅₅H₈₆O₂₄
SMILES	CC=C(C)C(=O)OC1C(OC(C)=O)C2(CO)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC6OC(CO)C(O)C(O)C6O)C(O)=O)C(C)(CO)C5CCC34C)C2CC1(C)C
Target	Apoptosis
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:1 mg/mL (0.88 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (0.88 mM)

Bioactivity

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In Vivo	Escin augments therapeutic effect of gemcitabine in BxPC-3 xenografts in nude mice. They have significant synergistic effects on suppressing the growth of pancreatic tumors, inhibiting the proliferation and inducing apoptosis of tumors. Escin potentiates the inhibiting effect of gemcitabine on NF-kB and NF-kB-regulated gene products in BxPC-3 xenografts in nude mice. Read more...
In Vitro	Escin is effective to inhibit pancreatic cancer cell proliferation as a single agent. However, escin has minimal effect on normal rat skeletal muscle cells. Escin potentiates the proliferation-inhibiting and apoptosis-inducing effect of gemcitabine in both BxPC-3 and PANC-1 cell lines in vitro. It also down-regulates constitutive as well as gemcitabine-induced activation of NF-kB and its downstream gene products in pancreatic cancer cells in vitro. Read more...
Cell Research	Cell cycle analysis: After treatment with escin (BxPC-3 (25 μM),PANC-1 (20 μM),respectively), gemcitabine (BxPC-3(100 nM), PANC-1(1 μM), respectively) or their combinations for 72 h, BxPC-3 and PANC-1 cells are collected by trypsinization, washed with ice-cold PBS and fixed overnight by the addition of 2 ml of ice-cold 70% ethanol/30% PBS at 4°C. The ethanol is subsequently removed after centrifugation, and about 1×106 cells are resuspended in 800 μl of PBS, 100 μl of ribonuclease A (500 g/ml PBS) and 100 μl of PI (500 g/ml PBS) in the dark at room temperature for 30 min. Flow cytometric analysis is performed using FACScan for the detection of the percentage of cells in the diVerent phases of the cell cycle. Cells treated with DMSO alone are used as controls. (Only for Reference) Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Apoptosis, Aescin, Inhibitor, Escin, inhibit

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Compound Identifiers

PubChem CID

4555259 ↗

Key Properties

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No computed properties available.

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Escin (orb1310765)

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Purity:	98.97% (May vary between batches)
CAS Number:	123748-68-5
MW:	1131.26
Formula:	C₅₅H₈₆O₂₄

Purity:	99.09% (May vary between batches)
CAS Number:	26339-90-2
MW:	1131.26
Formula:	C₅₅H₈₆O₂₄

Purity:	98.36% (May vary between batches)
CAS Number:	219944-46-4
MW:	1131.26
Formula:	C₅₅H₈₆O₂₄

Purity:	95.17% (May vary between batches)
CAS Number:	20977-05-3
MW:	1123.21
Formula:	C₅₄H₈₃NaO₂₃

Purity:	97.41% (May vary between batches)
CAS Number:	158732-55-9
MW:	1101.24
Formula:	C₅₄H₈₄O₂₃

Escin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Escin IIA [orb1684787]

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