Etomoxir

SKU: orb1689975

Description

Etomoxir is a potent and irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT1A), effectively blocking fatty acid oxidation. This small molecule is widely used in metabolic research, including studies on macrophage polarization, cardiac energetics, and cancer cell metabolism in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	124083-20-1
MW	326.82
Purity	98.00% (May vary between batches)
Formula	C₁₇H₂₃ClO₄
SMILES	C(OCC)(=O)[C@@]1(CCCCCCOC2=CC=C(Cl)C=C2)CO1
Target	CPT,Antioxidant,Apoptosis
Solubility	DMSO:250 mg/mL (764.95 mM);0.5% CMC-Na:12.5 mg/mL (38.25 mM)

Bioactivity

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Target IC50	KB cells (human):2.76 μM\|faTT cellsy acid (Hepatocyte cells,rat):10 μM\|faTT cellsy acid (Hepatocyte cells,guinea pig):1 μM\|faTT cellsy acid (Hepatocyte cells,human):0.1 μM Read more...
In Vivo	METHODS: To study the inhibition of cardiac CPT-I activity by Etomoxir, rats were injected with Etomoxir daily for 8 consecutive days at a dose of 20 mg/kg. RESULTS: Rats treated with Etomoxir showed a 44% reduction in cardiac CPT-I activity. METHODS: To study the effects of Etomoxir on blood glucose levels, weight gain, hind limb muscle mass, heart mass and liver mass, Lewis rats were treated with 20 mg/kgEtomoxir for 8 days. RESULTS: Treating Lewis rats with Etomoxir for 8 days did not change the blood glucose level, did not affect general growth characteristics such as weight gain, nor did it affect the muscle mass of the hind limbs. However, both the heart mass and liver mass increased significantly by 11%. Read more...
In Vitro	METHODS: A2780/PTX cells were treated with Etomoxir (1, 10, 100, 1000, 10000, 100000 nM) and paclitaxel (1, 10, 100, 1000, 10000, 100000 nM) for 48 hours, and the growth inhibition of the cells was detected by the CCK-8 method. RESULTS: The IC50 value of Etomoxir decreased from 1589.5 ± 62.5 nM to 817.4 ± 79.7 nM. Read more...

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Antioxidant, (R)-(+)-Etomoxir, CPT1, Etomoxir

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Compound Identifiers

PubChem CID

9840324 ↗

Key Properties

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No computed properties available.

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Etomoxir (orb1689975)

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Purity:	>98%
CAS Number:	828934-41-4
MW:	320.74
Formula:	C₁₅H₁₈ClO₄·Na

Purity:	>98%
CAS Number:	828934-43-6
MW:	321.751734972
Formula:	C₁₅H₁₉CLNAO₄

CAS Number:	828934-40-3
MW:	326.82
Formula:	C₁₇H₂₃ClO₄

Etomoxir

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Etomoxir (orb1689975)

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