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(±)-Evodiamine

SKU: orb1982007

Description

(±)-Evodiamine is a natural topoisomerase I inhibitor that suppresses adipogenesis and inflammation via modulation of IGF-1/HIF-1α, IL-6/STAT, and NF-κB pathways. It has been studied in vitro and in vivo for its roles in inhibiting cancer cell invasion, promoting apoptosis, and blocking TNF-induced Akt activation.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number518-18-3
MW303.36
Purity99.90%
FormulaC19H17N3O
SMILESCN1C2C3=C(C=4C(N3)=CC=CC4)CCN2C(=O)C=5C1=CC=CC5
TargetTopoisomerase,HIF,STAT,IGF-1R,IL Receptor,Apoptosis
SolubilityDMSO:8 mg/mL (26.37 mM);10% DMSO+90% Corn Oil:0.5 mg/mL (1.65 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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(±)-Evodiamine (orb1982007)

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1 ml x 10 mM (in DMSO)
$ 70.00
500 mg
$ 70.00
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