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FLI-06

SKU: orb1223155

Description

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which was accompanied by a tubule-to-sheet morphological transition of the ER. FLI-06 is the first small molecule acting at such an early stage in secretory traffic. Notch signaling has a pivotal role in numerous cell-fate decisions, and its aberrant activity leads to developmental disorders and cancer.

Images & Validation

Key Properties

CAS Number313967-18-9
MW438.52
Purity>98% (HPLC)
FormulaC25H30N2O5
SMILESCC1=C(C(c2ccc(cc2)[N+](=O)[O-])C2=C(CC(C)(C)CC2=O)N1)C(=O)OC1CCCCC1
TargetEpigenetic Reader Domain
SolubilityDMSO : ≥ 38 mg/mL; 86.66 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FLI06 | FLI 06 | FLI06

Similar Products

  • FLI-06 [orb1304567]

    >99.99% (May vary between batches)

    313967-18-9

    438.52

    C25H30N2O5

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg, 500 mg, 1 ml x 10 mM (in DMSO)
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FLI-06 (orb1223155)

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Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 120.00
10 mg
$ 160.00
25 mg
$ 260.00
50 mg
$ 450.00
100 mg
$ 760.00
500 mg
$ 1,620.00