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FLI-06

SKU: orb1304567

Description

FLI-06 is a cell-permeable small molecule inhibitor of the Notch signaling pathway, exhibiting an EC50 of 2.3 µM. It is a valuable research tool for investigating Notch-mediated processes in various cancer and developmental biology studies, applicable in both cellular and animal model systems.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number313967-18-9
MW438.52
Purity>99.99% (May vary between batches)
FormulaC25H30N2O5
SMILESCC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c1ccc(cc1)[N+]([O-])=O)C(=O)OC1CCCCC1
TargetGamma-secretase
SolubilityDMSO:60 mg/mL (136.82 mM);Ethanol:8.8 mg/mL (20.07 mM);10% DMSO+90% Saline:2.5 mg/mL (5.7 mM)

Bioactivity

Target IC50
Notch:2.3 μM(EC50)
In Vivo
In kidney epithelial 293 cells, stable transfection of mutant APP results in significant amyloid deposition. FLI-06 alters the maturation pattern of the APP, subsequently terminating the release of APPs. Furthermore, in Hela cells overexpressing Notch green fluorescent protein, FLI-06 inhibits Notch transport and progression. FLI-06 disrupts the Golgi apparatus and inhibits the secretion of pre-transport proteins in the endoplasmic reticulum during the tubular to sheet-like morphology transition.
In Vitro
In zebrafish embryos, FLI-06 at a concentration of 50µM inhibits the endogenous Notch signaling pathway.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Notch, inhibit, FLI 06, FLI06, FLI-06, Inhibitor, Gammasecretase

Similar Products

  • FLI-06 [orb1223155]

    >98% (HPLC)

    313967-18-9

    438.52

    C25H30N2O5

    1 g, 500 mg, 5 mg, 25 mg, 50 mg, 100 mg, 2 mg, 10 mg
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Key Properties

No computed properties available.

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Protocol Information

FLI-06 (orb1304567)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 150.00
25 mg
$ 230.00
50 mg
$ 370.00
100 mg
$ 620.00
500 mg
$ 1,290.00
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