Fondaparinux sodium

SKU: orb1223419

Description

Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII).(In Vitro):Fondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. For Fondaparinux, its IC50 values (anti-Xa IU/ml) are 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs).(In Vivo):Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug does not affect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function or aggregation.

Images & Validation

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Key Properties

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CAS Number	114870-03-0
MW	1729.09
Purity	>98% (HPLC)
Formula	C₃₁H₄₄N₃Na₁₀O₄₉S₈
SMILES	[C@H]1([C@H]([C@@H](O[C@@H]2[C@@H](O[C@H]([C@@H]([C@H]2O)OS(=O)(=O)[O-])O[C@H]2[C@@H]([C@H]([C@H](O[C@@H]2COS(=O)(=O)[O-])OC)NS(=O)(=O)[O-])O)C(=O)[O-])O[C@@H]([C@H]1O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H]([C@H]([C@@H]([C@H](O1)COS(=O)(=O)[O-])O)O)NS(=O)(=O)[O-])C(=O)[O-])COS(=O)(=O)[O-])NS(=O)(=O)[O-])OS(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Target	Factor Xa
Solubility	H2O : ≥ 30 mg/mL 17.26 mM

Bioactivity

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In Vivo

Fondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug does not affect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function or aggregation.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Fondaparinux sodium | PENTA | Arixtra

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Gene Symbol

Factor Xa

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