Fondaparinux sodium

SKU: orb1303188

Description

Fondaparinux sodium is a synthetic antithrombin-mediated selective factor Xa inhibitor. It is widely used in preclinical research to study thrombosis and hemostasis, serving as a key tool in both in vitro coagulation assays and in vivo models of venous thromboembolism.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	114870-03-0
MW	1728.08
Purity	98.00%
Formula	C₃₁H₄₃N₃Na₁₀O₄₉S₈
SMILES	[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4O)C([O-])=O)[C@H](OS([O-])(=O)=O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Target	Factor Xa
Solubility	H2O:17.36 mM;DMSO:60 mg/mL (34.72 mM)

Bioactivity

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In Vivo

Fondaparinux sodium exhibits a linear, dose-dependent pharmacokinetic profile ensuring a highly predictable response. It is fully bioavailable (100%), with a quick onset and a half-life of 14 to 16 hours, providing prolonged antithrombotic effects throughout a 24-hour period. Notably, the drug does not impact prothrombin time, activated partial thromboplastin time, or platelet function and aggregation.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Arixtra, Natural heparin pentasaccharide Sodium, inhibit, Fondaparin, Fondaparin sodium, Fondaparinux, Fondaparinux sodium, FactorXa, Factor Xa, Fxa, Inhibitor, SR-90107A

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Compound Identifiers

PubChem CID

636380 ↗

Key Properties

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No computed properties available.

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