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FOY 251

SKU: orb1298722

Description

FOY 251, the active metabolite of camostat, is a serine protease inhibitor. It is widely used in research to study protease functions in vitro and has been applied in vivo to investigate inflammatory and viral entry mechanisms, including those involving TMPRSS2.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Images & Validation

Key Properties

CAS Number71079-09-9
MW409.41
Purity99.33% (May vary between batches)
FormulaC17H19N3O7S
SMILESCS(O)(=O)=O.NN=CNc1ccc(cc1)C(=O)Oc1ccc(CC(O)=O)cc1
TargetSerine/threonin kinase,Serine Protease,SARS-CoV
Solubility10% DMSO+90% Corn Oil:2 mg/mL (4.89 mM);DMSO:25 mg/mL (61.06 mM)

Bioactivity

In Vitro
FOY-251, an active metabolite of camostat mesilate, on sodium transport in the mouse cortical collecting duct cell line (M-1 cells) and on blood pressure in Dahl salt-sensitive rats. Treatment with camostat mesilate or FOY-251 decreased equivalent current (Ieq) in M-1 cells in a dose-dependent manner and inhibited the protease activity of prostasin in vitro.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

camostate, obese, metabolism, inhibit, FOY 251, FOY251, FOY-251, Inhibitor, Serine kinase, Serine endopeptidases, Ser/Thr Protease, Serine proteases, threonin kinase, Serinekinase, threoninkinase, Threonine proteases, proteinase, proteolytic, SARS coronavirus, SARSCoV, SARS-CoV

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

FOY 251 (orb1298722)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 90.00
5 mg
$ 160.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 240.00
25 mg
$ 380.00
50 mg
$ 520.00
100 mg
$ 720.00
500 mg
$ 1,370.00
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