GLP-1 (9-36) amide

SKU: orb1679131

Description

GLP-1 (9-36) amide is a GLP-1 receptor antagonist that potently suppresses hepatic glucose production and exhibits mild insulinotropic activity. This metabolite is a valuable research tool for studying glucose metabolism, insulin secretion, and receptor pharmacology in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	161748-29-4
MW	3089.41
Purity	97.00%
Formula	C₁₄₀H₂₁₄N₃₆O₄₃
SMILES	CC[C@H](C)[C@@H](C(N[C@@H](C)C(N[C@@H](Cc1c[nH]c2c1cccc2)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](Cc1ccccc1)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](Cc(cc1)ccc1O)NC([C@H](CO)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](Cc1ccccc1)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CCC(O)=O)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Target	Glucagon Receptor
Solubility	0.025% acetic acid:2 mg/mL (0.65 mM)

Bioactivity

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In Vivo

After subcutaneous (s.c.) administration of GLP-1 to dogs the plasma immunoreactivity of GLP-1 measured by two different radioimmunoassays (RIAs) were higher than that measured by a sandwich enzyme-linked immunosorbent assay (ELISA). This discrepancy was due to the formation of the metabolites GLP-1-(9-36) amide, GLP-1-(7-35) and GLP-1-(7-34). Receptor binding studies using baby hamster kidney cells expressing the human pancreatic GLP-1 receptor showed that the affinity of GLP-1-(9-36) amide was 0.95% of the affinity of GLP-1-(7-36) amide. Furthermore, GLP-1-(9-36) amide was shown to be an antagonist to adenylyl cyclase activity. GLP-1-(9-36) amide was shown to be present in vivo in amounts up to 10-fold that of GLP-1-(7-36) amide.

Storage & Handling

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Storage	store at low temperature,keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Glucagon Receptor, GlucagonReceptor, GLP 1, GLP 1 (9 36) amide, GLP-1, GLP-1 Amide, GLP1 (936) amide, GLP1, Inhibitor, GCGR

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Compound Identifiers

PubChem CID

90488821 ↗

Key Properties

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No computed properties available.

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GLP-1 (9-36) amide (orb1679131)

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Purity:	> 95% by HPLC
MW:	3089.4 Da
Structure:	H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Purity:	> 95%
MW:	3089.48
Source:	Synthetic

Purity:	≥95%
MW:	3089.48

GLP-1 (9-36) amide

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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