Glucocorticoid receptor modulator 1

SKU: orb1745131

Description

This potent, orally bioavailable small molecule acts as a dual inhibitor of NF-κB and AP-1 signaling pathways, with IC50 values of 9 nM and 130 nM, respectively. It effectively suppresses pro-inflammatory mediators like IL-6, TNF-α, and MMP-13, demonstrating utility for researching inflammatory skin disease models both in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2868357-11-1
MW	470.97
Purity	99.79%
Formula	C₂₄H₂₃ClN₂O₄S
SMILES	O=C(C=1C=CC=CC1)N2C3=CC=C(C=C3CCC2)NS(=O)(=O)C=4C=C(Cl)C(=CC4OC)C
Target	DNA/RNA Synthesis,Glucocorticoid Receptor,TNF,IL Receptor,NF-κB,MMP
Solubility	DMSO:80 mg/mL (169.86 mM)

Bioactivity

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In Vitro	Methods: RAW264.7 cells were treated with Glucocorticoid receptor modulator 1 (10 μM, 24 hours), and the expression of related mRNA was detected by qPCR. Results: Glucocorticoid receptor modulator 1 reduced the mRNA expression of inflammatory factors such as IL-6, IL-1β, TSLP, MMP-13, TNF-α and CCL-2 in RAW264.7 cells. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

166176961 ↗

Key Properties

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No computed properties available.

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