GS-441524

SKU: orb1299964

Description

GS-441524

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	1191237-69-0
MW	291.26
Purity	99.90%
Formula	C₁₂H₁₃N₅O₄
SMILES	Nc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N
Target	DNA/RNA Synthesis,SARS-CoV
Solubility	DMSO:247.5 mg/mL (849.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.87 mM)

Bioactivity

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Target IC50	FIPV:0.78 μM (EC50)
In Vivo	Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy. Read more...
Animal Research	Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, feline, FIPV, GS441524, GS-441524, GS441524 Triphosphate, GS-441524 Triphosphate, GS 441524, peritonitis, RNA Synthesis, RNASynthesis, SARSCoV, SARS coronavirus, SARS-CoV, virus

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Compound Identifiers

PubChem CID

44468216 ↗

Key Properties

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No computed properties available.

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GS-441524 (orb1299964)

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Purity:	99.52% (May vary between batches)
CAS Number:	2647442-13-3
MW:	501.53
Formula:	C₂₄H₃₁N₅O₇

CAS Number:	2691076-98-7
MW:	401.42
Formula:	C₁₉H₂₃N₅O₅

CAS Number:	2563617-99-0
MW:	501.54
Formula:	C₂₄H₃₁N₅O₇

CAS Number:	2250110-53-1
MW:	718.656
Formula:	C₃₁H₃₉N₆O₁₂P

Purity:	99.91%
CAS Number:	2378515-04-7
MW:	392.9
Formula:	C₁₉H₂₁ClN₂O₃S

GS-441524

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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