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GW-870086

SKU: orb1219520

Description

GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB). GW-870086 (10-100 nM) obviously increases fibronectin secretion. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor, or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin.

Images & Validation

Key Properties

CAS Number827319-43-7
MW559.64
Purity>98% (HPLC)
FormulaC31H39F2NO6
SMILES[H][C@@]12C[C@@H](C)[C@](OC(=O)C3C(C)(C)C3(C)C)(C(=O)OCC#N)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
Targetglucocorticoid receptor
SolubilityIn Vitro: DMSO : 100 mg/mL (178.69 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • GW-870086 [orb1308240]

    99.86% (May vary between batches)

    827319-43-7

    559.64

    C31H39F2NO6

    2 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg, 5 mg
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GW-870086 (orb1219520)

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Available Sizes

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 190.00
25 mg
$ 290.00
50 mg
$ 500.00
100 mg
$ 730.00