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GW-870086

SKU: orb1308240

Description

GW-870086 is a potent glucocorticoid receptor agonist with anti-inflammatory activity, demonstrating a pIC50 of 10.1 in NF-κB reporter assays using A549 cells. It is a valuable research tool for studying glucocorticoid receptor signaling and inflammation in both cellular and animal models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number827319-43-7
MW559.64
Purity99.86% (May vary between batches)
FormulaC31H39F2NO6
SMILES[H][C@@]12C[C@@H](C)[C@](OC(=O)C3C(C)(C)C3(C)C)(C(=O)OCC#N)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
TargetGlucocorticoid Receptor
SolubilityDMSO:11 mg/mL (19.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.57 mM)

Bioactivity

In Vitro
GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin. GW-870086 (GW870086X; 10-100 nM) obviously increases fibronectin secretion.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, GW870086, GW-870086, GW 870086, GlucocorticoidReceptor, Glucocorticoid Receptor, glucocorticoid receptor, glucocorticoid receptor, A549 NF-κB cells, inhibit

Similar Products

  • GW-870086 [orb1219520]

    >98% (HPLC)

    827319-43-7

    559.64

    C31H39F2NO6

    1 g, 500 mg, 200 mg, 25 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

GW-870086 (orb1308240)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 120.00
25 mg
$ 160.00
50 mg
$ 270.00
100 mg
$ 370.00
200 mg
$ 520.00
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