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GW280264X

SKU: orb1217567

Description

GW280264X is an inhibitor of ADAM17 .

Images & Validation

Key Properties

CAS Number866924-39-2
MW575.72
Purity>98% (HPLC)
FormulaC28H41N5O6S
SMILESCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCC1=CC=CC=C1)C(=O)NC2=NC=CS2)N(C=O)O
TargetADAM17
SolubilityDMSO:10 mM

Bioactivity

In Vivo
Animal model: C57BL/6 mice. Dosage: 100 μg/kg. Administration: i.p. injected; every day for one week starting 4 h post-surgery. Result: Showed significantly improved functional recovery compared to the control group.
In Vitro
Cell Viability Assay Cell line: Glioblastoma-initiating cells (GIC) GS-7 cells. Concentration: 0.1, 1, and 3 μM Incubation time: 48 hours. Result: Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Carbamic acid

Similar Products

  • GW280264X [orb1298489]

    99.51% (May vary between batches)

    866924-39-2

    575.72

    C28H41N5O6S

    1 mg, 5 mg, 10 mg, 25 mg, 100 mg, 1 ml x 10 mM (in DMSO), 50 mg
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GW280264X (orb1217567)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 490.00
10 mg
$ 710.00
25 mg
$ 1,130.00
50 mg
$ 1,540.00
100 mg
$ 2,060.00