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GW280264X

SKU: orb1298489

Description

GW280264X is a potent and selective small molecule inhibitor of ADAM17 (TACE). It is widely used in biochemical and cellular research to investigate the protease's role in ectodomain shedding of TNF-α and other substrates in both in vitro and in vivo models.

Research Area

Protein Biochemistry

Images & Validation

Key Properties

CAS Number866924-39-2
MW575.72
Purity99.51% (May vary between batches)
FormulaC28H41N5O6S
SMILESCCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)Nc1nccs1)N(O)C=O
TargetMMP
Solubility10% DMSO+90% Corn Oil:1 mg/mL (1.74 mM);DMSO:11 mg/mL (19.11 mM)

Bioactivity

Target IC50
ADAM17:8 nM (IC50)|ADAM10:11.5 nM (IC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

TACE, stem, Matrix metalloproteinases, immunogenicity, GIC, glioblastoma, GW280264X, GW-280264X, immunotherapy, inhibit, Inhibitor, MMP, Mixed, metalloproteinases, ADAM17, ADAM10, Carbamic acid

Similar Products

  • GW280264X [orb1217567]

    >98% (HPLC)

    866924-39-2

    575.72

    C28H41N5O6S

    50 mg, 25 mg, 5 mg, 10 mg, 1 g, 500 mg, 200 mg, 100 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

GW280264X (orb1298489)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 210.00
5 mg
$ 400.00
1 ml x 10 mM (in DMSO)
$ 490.00
10 mg
$ 570.00
25 mg
$ 900.00
50 mg
$ 1,220.00
100 mg
$ 1,630.00
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