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Hexa-D-arginine

SKU: orb1220312

Description

Hexa-D-arginine is an inhibitor of furinblocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

Images & Validation

Key Properties

CAS Number673202-67-0
MW954.14
Purity>98% (HPLC)
FormulaC36H75N25O6
SMILESC(C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N)N)CN=C(N)N
Targetfurin
SolubilityIn Vitro: H2O : 50 mg/mL (52.40 mM)

Bioactivity

In Vivo
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
In Vitro
Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Hexa-D-arginine (orb1220312)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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200 mg
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5 mg
$ 240.00
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25 mg
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50 mg
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100 mg
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