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Hexa-D-arginine

SKU: orb1299770

Description

Hexa-D-arginine is a furin protease inhibitor that prevents the proteolytic activation of Pseudomonas aeruginosa exotoxin A. This mechanism makes it a valuable research tool for studying bacterial pathogenesis and furin-dependent processing events in both cellular and animal models.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number673202-67-0
MW954.14
Purity>99.99% (May vary between batches)
FormulaC36H75N25O6
SMILESN[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(N)=O
TargetAntibacterial,Others
SolubilityH2O:50 mg/mL (52.4 mM);DMSO:20 mg/mL (20.96 mM)

Bioactivity

Target IC50
Furin:106 nM (KI)|PACE4:580 nM (KI)|PC1:13.2 mM (ki)
In Vivo
The small stable furin inhibitor hexa-D-arginine amide effectively blocks PEA-induced cell lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

anthrax, inhibit, noncytotoxic, PACE4, PC1, Inhibitor, Hexa D arginine, HexaDarginine, Hexa-D-arginine, exotoxins, furin, Furin Inhibitor II, TNF-α, PEA

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Quality Guarantee

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Key Properties

No computed properties available.

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Hexa-D-arginine (orb1299770)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 210.00
10 mg
$ 310.00
25 mg
$ 490.00
50 mg
$ 690.00
100 mg
$ 930.00
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