Hydroxychloroquine sulfate

SKU: orb1224083

Description

Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.(In Vitro):Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA). Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands.(In Vivo):Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	747-36-4
MW	433.95
Purity	>98% (HPLC)
Formula	C₁₈H₂₆ClN₃O·H₂SO₄
SMILES	CCN(CCO)CCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C.O=S(O)(O)=O
Target	DNA Alkylator
Solubility	Water: 67 mg/mL (154.39 mM)

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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HCQ | NSC 4375

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Gene Symbol

DNA Alkylator

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