Hydroxychloroquine sulfate

SKU: orb1310137

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Description

Hydroxychloroquine sulfate is a research compound that acts as an antimalarial by inhibiting plasmodial heme polymerase within the parasite's food vacuole. It is widely used in parasitology and immunology research, including in vitro studies of Plasmodium falciparum and in vivo models of autoimmune diseases.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	747-36-4
MW	434.0
Purity	>98%
Formula	C₁₈H₂₆ClN₃O ∙ H₂SO₄
SMILES	OS(=O)(=O)O.CCN(CCO)CCCC(C)Nc1c2ccc(Cl)cc2ncc1
Target	Lysosome
Solubility	Soluble in Water (up to 40 mg/ml).

Bioactivity

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In Vivo	The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals. Read more...
In Vitro	Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis. Read more...
Cell Research	All cells are cultured in RPMI with 10% FBS, 1% glutamine, and 1% Pen/Strep. cells are seeded on the appropriated plates overnight and treated with HCQ (75 or 100 μM) for 48 hours.(Only for Reference) Read more...

Storage & Handling

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Storage	RT
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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SARS coronavirus, SARSCoV, SARS-CoV, TLR9, TLR, Toll-like Receptor (TLR), Autophagy, Acidum iopanoicum, DNA, Inhibitor, inhibit, Parasite, Hydroxychloroquine, Hydroxychloroquine sulfate, Hydroxychloroquine Sulfate, HCQ, HCQ sulfate, HCQ Sulfate

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Compound Identifiers

PubChem CID

12947 ↗

Key Properties

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No computed properties available.

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