IC261

SKU: orb1305484

Description

IC261 (SU-5607) is a selective casein kinase 1 (CK1) inhibitor with an IC50 of 16 µM, which is significantly more potent than its activity against Cdk5 (IC50 4.5 mM). It activates the mitotic checkpoint and is widely used in vitro to study cell cycle regulation, apoptosis, and circadian rhythms.

Research Area

Cell Biology, Metabolism Research, Stem Cell & Developmental Biology

Images & Validation

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Key Properties

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CAS Number	186611-52-9
MW	311.33
Purity	99.91% (May vary between batches)
Formula	C₁₈H₁₇NO₄
SMILES	COc1cc(OC)c(\C=C2\C(=O)Nc3ccccc23)c(OC)c1
Target	Apoptosis,CDK,Casein Kinase
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.42 mM);DMSO:70 mg/mL (224.84 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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Target IC50	CKIδ:1 μM\|CDK5:4.5 mM.\|CK1:16 μM
In Vivo	Intrathecal injection of a CK1 inhibitor IC261 attenuates neuropathic pain behaviors. CK1 inhibitors are found to be effective in reducing spinal excitatory response elicited by the presynaptic electrical stimulation only in neuropathic mice. Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo. Read more...
In Vitro	IC261 leads to a p53-dependent arrest of the cells with a DNA content of 4 N. It can produce effects on cell cycle progression that are indistinguishable from an established spindle poison and are dependent on the p53 status of the cells. Read more...
Cell Research	Cultures of MEFs of di erent genotypes (p53+/+, p53+/7, p537/7) are treated with the inhibitor IC261 in the low micromolar range (1 μM). After 12, 24, 48 hours exposure, the effects of IC261 on cell cycle distribution are measured by flow cytometry.(Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CDK5, CK1, Casein Kinase, CaseinKinase, Apoptosis, inhibit, Inhibitor, IC-261, IC261, IC 261, SU 5607, SU5607, SU-5607

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Compound Identifiers

PubChem CID

5288600 ↗

Key Properties

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No computed properties available.

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IC261 (orb1305484)

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Purity:	>98% (HPLC)
CAS Number:	301836-43-1
MW:	398.414
Formula:	C₂₃H₁₈N₄O₃

Purity:	>98% (HPLC)
CAS Number:	186611-52-9
MW:	311.3319
Formula:	C₁₈H₁₇NO₄

IC261

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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