Icaritin

SKU: orb1222830

Description

Icaritin is an oral traditional Chinese medicine, derived from barrenwort, which targets the estrogen receptor α36. IC50 values for Icaritin are 8,13 and 18 μM for K562, CML-CP and CML-BC cells respectively. Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1α signalling. Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.

Images & Validation

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Key Properties

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CAS Number	118525-40-9
MW	368.38
Purity	>98% (HPLC)
Formula	C₂₁H₂₀O₆
SMILES	CC(=CCc1c(cc(c2c1oc(c(c2=O)O)c1ccc(cc1)OC)O)O)C
Target	JAK2\| STAT3
Solubility	DMSO : 14 mg/mL 38.00 mM;

Bioactivity

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In Vivo

Animal model: Female NOD-SCID nude mice (6-8 weeks old) with K562 cells. Dosage: 4 mg/kg and 8 mg/kg. Administration: Intraperitoneal injection; daily; for 10 weeks. Result: Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow.

In Vitro

Cell Proliferation Assay Cell line: K562, imatinib-resistant cells and primary CML cells. Concentration: 4 μM, 8 μM, 16 μM, 32 μM and 64 μM. Incubation time: 48 hours. Result: Inhibited cell proliferation. Apoptosis Analysis Cell line: K562 or primary cells. Concentration: 0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM. Incubation time: 48 hours. Result: Induced K562 or primary cells apoptosis. Cell Cycle Analysis Cell line: K562 cells. Concentration: 32 μM. Incubation time: Result: Cell population in the sub-G1 phase was increased. Western blot analysis. Cell line: K562 cells. Concentration: 0 μM, 4 μM, 8 μM, 16 μM, 32 μM and 64 μM. Incubation time: 48 hours. Result: Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Icaritin

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JAK2| STAT3

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Icaritin (orb1222830)

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CAS Number:	108195-76-2
MW:	532.54
Formula:	C₂₇H₃₂O₁₁

Purity:	98.98%
CAS Number:	118525-40-9
MW:	368.38
Formula:	C₂₁H₂₀O₆

CAS Number:	2922842-01-9
MW:	611.68
Formula:	C₃₃H₄₁NO₁₀

Purity:	>98% (HPLC)
CAS Number:	1446712-19-1
MW:	406.3519
Formula:	C₂₁H₁₇F₃O₅

Icaritin

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Icaritin (orb1222830)

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