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Ilexgenin A

SKU: orb1304696

Description

Ilexgenin A is a novel pentacyclic triterpenoid isolated from Ilex hainanensis Merr. Research indicates it exhibits anti-inflammatory and antioxidant activities, making it a compound of interest for metabolic and cardiovascular disease studies in vitro and in vivo.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number108524-94-3
MW502.68
Purity99.75%
FormulaC30H46O6
SMILES[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)CC[C@H](O)[C@]2(C)C(O)=O
TargetTNF,IL Receptor
SolubilityDMSO:11 mg/mL (21.88 mM);10% DMSO+90% Corn Oil:1 mg/mL (1.99 mM)

Bioactivity

In Vitro
Ilexgenin A (IA), a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr.treatment with IA attenuated atherosclerosis in high-fat diet-induced apolipoprotein E deficient mice via a series of effects involving regulation of lipid parameters, decrease of atherosclerosis-related indexes, inhibition of inflammatory cytokines secretion and pathological changes of main organs. The underlying mechanism of IA was investigated on oxidized low-density lipoprotein (Ox-LDL)-induced THP-1 cells. Pre-treatment with IA decreased active inflammation cytokines involving interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α) expression in a concentration-dependent manner.IA inhibited the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), IKKα phosphorylation and NF-κB activity induced by Ox-LDL. Overall, these findings define IA as a novel drug candidate for anti-atherosclerotic therapy.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Akt, Caspase, cancer, AMPK, LDL, IkB, IL Receptor, hainanensis, ERK, Inhibitor, inhibit, inflammation, ILReceptor, Ilex, Ilexgenin A, NF-κB, NO, pentacyclic, PKC, PI3K, ROS, TNF-α, STAT, triterpenoid, VEGFR

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Key Properties

No computed properties available.

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Ilexgenin A (orb1304696)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
5 mg
$ 200.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 280.00
25 mg
$ 410.00
50 mg
$ 580.00
100 mg
$ 810.00
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