Indirubin Derivative E804

SKU: orb1709411

Description

E804, an indirubin derivative, is a potent and selective inhibitor of the insulin-like growth factor 1 receptor (IGF1R). It demonstrates antitumor activity in vitro and has shown efficacy in reducing tumor growth in preclinical in vivo models, supporting its investigation in cancer research.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	854171-35-0
MW	365.38
Purity	98.75% (May vary between batches)
Formula	C₂₀H₁₉N₃O₄
SMILES	O=C1NC=2C=CC=CC2C1=C3NC=4C=CC=CC4C3=NOCCC(O)CO
Target	IGF-1R
Solubility	DMSO:100 mg/mL (273.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.95 mM)

Bioactivity

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Target IC50	IGF-1R:0.65 μM\|CDK2-CyclinE:0.23 μM (EC50)
In Vitro	Indirubin Derivative E804 is a water-soluble derivative that effectively inhibits insulin-like growth factor 1 receptor (IGF1R) with an IC50 of 0.65 μM. In addition, Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM. Read more...

Storage & Handling

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Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Indirubin Derivative E804, Indirubin Derivative E-804, Indirubin Derivative E 804, IGF-1R, IGF1R

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Compound Identifiers

PubChem CID

136218975 ↗

Key Properties

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No computed properties available.

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