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Indirubin E804

SKU: orb2655624

Description

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro; decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin; inhibits the subintestinal vessels formation in zebrafish embryos.

Images & Validation

Key Properties

CAS Number854171-35-0
MW365.389
Purity>98% (HPLC)
FormulaC20H19N3O4
SMILESC1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=NOCCC(CO)O
TargetSTAT
SolubilityIn Vitro: DMSO : 125 mg/mL (342.11 mM)

Bioactivity

In Vitro
Indirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

E804

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    1 mg, 25 mg, 100 mg, 10 mg, 5 mg, 50 mg, 200 mg, 1 ml x 10 mM (in DMSO)
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Indirubin E804 (orb2655624)

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