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Juglone

SKU: orb1221220

Description

Juglone is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family including human Pin1 yeast Ess1/Ptf1 and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I II and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction both through Pin1-independent mechanisms.
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Images & Validation

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Juglone

Key Properties

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CAS Number481-39-0
MW174.15
Purity>98% (HPLC)
FormulaC10H6O3
SMILESOc1cccc2C(=O)C=CC(=O)c12
TargetDNA/RNA Synthesis
SolubilityDMSO: 15 mg/mL;Ethanol: 15 mg/mL

Bioactivity

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In Vivo
Animal model: High-fat diet rats model. Dosage: 0.25 or 1 mg/kg. Administration: p.o. Result: Regulated the expression of s TNF-α, IL-1β and IL-6.Inhibited the TLR4 expression and NF-kappa activity.
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In Vitro
Cell Cytotoxicity Assay Cell line: SGC-7901. Concentration: 5, 10, 15, 20 μM. Incubation time: 24 h. Result: Inhibited cell growth in a dose-dependent manner. Apoptosis Analysis Cell line: SGC-7901. Concentration: 5, 10, 15, 20 μM. Incubation time: 24 h. Result: Increased the number of early apoptotic cells. Western blot analysis. Cell line: SGC-7901. Concentration: 5, 10, 15, 20 μM. Incubation time: 24 h. Result: Decreased the expression of Bcl-2 and increased the Bax protein.
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Storage & Handling

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StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Regianin | 5-Hydroxy-14-naphthoquinone

Similar Products

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  • Juglone

    Juglone [orb1303312]

    99.24%

    481-39-0

    174.15

    C10H6O3

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg
  • Juglone (Standard)

    Juglone (Standard) [orb3139237]

    481-39-0

    174.15

    C10H6O3

    25 mg
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DNA/RNA Synthesis

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Juglone (orb1221220)

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% DMSO +
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% Tween 80 +
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5 mg
$ 90.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 210.00
100 mg
$ 270.00
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