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Juglone

SKU: orb1303312

Description

Juglone (Regianin, CAS 481-39-0) is a natural compound that potently inhibits Pin1 and other parvulin-family PPIases (Ki = 55.9 nM). It also blocks eukaryotic RNA polymerases (IC50 2-7 µM) and has demonstrated in vivo activity in attenuating kidney fibrosis in rodent models, acting through both Pin1-dependent and independent mechanisms.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Molecular Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number481-39-0
MW174.15
Purity99.24%
FormulaC10H6O3
SMILESOc1cccc2C(=O)C=CC(=O)c12
TargetTLR,DNA/RNA Synthesis,Antibacterial,NF-κB,Apoptosis
SolubilityDMSO:5.56 mg/mL (31.93 mM);Ethanol:15 mg/mL (86.13 mM)

Storage & Handling

Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

DNA Synthesis, DNASynthesis, 5-Hydroxy-1,4-naphthoquinone, antimicrobial, Bacterial, black, Inhibitor, Juglone, inhibit, RNA polymerase, RNA Synthesis, RNASynthesis, walnut, Regianin, Pigment, Yellow

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Key Properties

No computed properties available.

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Juglone (orb1303312)

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5 mg
$ 90.00
10 mg
$ 100.00
25 mg
$ 140.00
50 mg
$ 180.00
100 mg
$ 230.00
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