Licarin A

SKU: orb1705457

Description

Licarin A is a naturally occurring lignan with demonstrated anti-inflammatory activity. It functions by inhibiting the PKCα/βII and p38 MAPK signaling pathways, which subsequently reduces TNF-α and prostaglandin D2 release as well as COX-2 expression. This compound is utilized in vitro for researching inflammation mechanisms in models such as macrophages.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	51020-86-1
MW	326.39
Purity	99.50%
Formula	C₂₀H₂₂O₄
SMILES	O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1
Target	p38 MAPK,Prostaglandin Receptor,TNF,COX
Solubility	DMSO:40 mg/mL (122.55 mM);H2O:< 0.1(insoluble)

Bioactivity

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In Vitro

Methods: DNP-HSA-stimulated RBL-2H3 cells were treated with Licarin A (0-20 μM) to study the antiallergic effect on antigen-stimulated rat mast cell line. Results: The level of PGD2 secretion in DNP-HSA-stimulated cells pretreated with Licarin A was lower than that in cells stimulated with DNP-HSA alone (positive control); 20 μM Licarin A treatment produced a slight inhibition of DNP-HSA-induced increase in COX-2 mRNA and protein levels; Licarin A reduced TNF-α and PGD2 secretion by inhibiting PKCα/βII and p38 MAPK pathways; this compound may be useful in alleviating immediate hypersensitivity reactions.

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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(-)-Licarin A, NSC 370989, NSC-370989, NSC370989, Licarin A

Quality Guarantee

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Compound Identifiers

PubChem CID

6442393 ↗

Key Properties

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No computed properties available.

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Licarin A (orb1705457)

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CAS Number:	42016-15-9
MW:	324.37
Formula:	C₂₀H₂₀O₄

Purity:	99.82%
CAS Number:	51020-87-2
MW:	324.37
Formula:	C₂₀H₂₀O₄

CAS Number:	23518-30-1
MW:	326.39
Formula:	C₂₀H₂₂O₄

Purity:	>98% (HPLC)
CAS Number:	51020-87-2
MW:	324.37
Formula:	C₂₀H₂₀O₄

Purity:	>98% (HPLC)
CAS Number:	51020-86-1
MW:	326.39
Formula:	C₂₀H₂₂O₄

Licarin A

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

(+)-Licarin [orb1941173]

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(±)-Licarin A [orb1707915]

(-)-Licarin B [orb1222142]

Licarin A b [orb3054615]

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Key Properties

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Licarin A (orb1705457)

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