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LJI308

SKU: orb1223260

Description

LJI308 is a RSK inhibitor. LJI308 overcomes chemoresistance by eliminating cancer stem cells. LJI308 targets the CSC population and repress TNBC growth and dissemination. LJI308 specifically targeted transformed cells as it had little effect on the non-tumorigenic parental HMECs. Targeting RSK using specific and potent inhibitors, such as LJI308, delivers the promise of inhibiting the growth of TNBC.

Images & Validation

Key Properties

CAS Number1627709-94-7
MW368.38
Purity>98% (HPLC)
FormulaC21H18F2N2O2
SMILESOc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1
TargetPDE
SolubilityDMSO : ≥ 32 mg/mL 86.87 mM

Bioactivity

In Vitro
LJI308 inhibits S6K1 with an IC50 of 0.8 μM. LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells. LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%. Cell Viability Assay Cell line: HTRY-LT cell lines. Concentration: 1-10 μM. Incubation time: 96 hours. Result: Decreased cell viability by up to 90%.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

LJI308 | LJI-308 | LJI 308 | NVP-LJI308 | NVP-LJI-308

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  • LJI308 [orb1300383]

    99.87%

    1627709-94-7

    368.38

    C21H18F2N2O2

    10 mg, 25 mg, 1 mg, 1 ml x 10 mM (in DMSO), 100 mg, 5 mg, 50 mg
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LJI308 (orb1223260)

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Available Sizes

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200 mg
500 mg
5 mg
$ 140.00
10 mg
$ 160.00
25 mg
$ 320.00
50 mg
$ 480.00
100 mg
$ 720.00