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LJI308

SKU: orb1300383

Description

LJI308 is a potent and pan-RSK inhibitor, exhibiting IC50 values of 6 nM (RSK1), 4 nM (RSK2), and 13 nM (RSK3). This small molecule is a valuable research tool for studying RSK signaling in cancer cell proliferation and survival, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number1627709-94-7
MW368.38
Purity99.87%
FormulaC21H18F2N2O2
SMILESOc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1
TargetY Box Binding Protein 1,S6 Kinase
Solubility10% DMSO+90% Corn Oil:2.5 mg/mL (6.79 mM);H2O:Insoluble;DMSO:50 mg/mL (135.73 mM)

Bioactivity

Target IC50
RSK3:13 nM|RSK1:6 nM|RSK2:4 nM
In Vitro
In MDA-MB-231 and H358 cells, LJI308 blocks cellular inhibition of RSK and its phosphorylation of YB1 on Ser102 with EC50 of 0.2–0.3 μM, and thus inhibits cell growth. In TNBC HTRY-LT cells, LJI308 also suppresses cell growth correlative with YB-1 inhibition.
Cell Research
Cell growth under attached conditions is assessed by plating 1000 cells per well on 96-well tissue culture-treated plates in cell growth medium. Appropriate dilutions of compound are 4 added medium above cells and cell growth was assessed after 72 hrs by addition of CellTiter Glo reagent according to manufacturer’s directions. (Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cancer, breaks, double-strand, Inhibitor, LJI 308, LJI308, LJI-308, mutation, inhibit, phosphorylation, stimulation, RSK1, RSK2, RSK3, S6 Kinase, S6K, S6Kinase, Ribosomal S6 Kinase (RSK), viability

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  • LJI308 [orb1223260]

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    1627709-94-7

    368.38

    C21H18F2N2O2

    1 g, 500 mg, 200 mg, 50 mg, 100 mg, 10 mg, 25 mg, 5 mg
Quality Guarantee

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Key Properties

No computed properties available.

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LJI308 (orb1300383)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 130.00
5 mg
$ 130.00
10 mg
$ 140.00
25 mg
$ 270.00
50 mg
$ 400.00
100 mg
$ 580.00
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