Lucanthone

SKU: orb1302749

Description

Lucanthone

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Images & Validation

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Key Properties

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CAS Number	479-50-5
MW	340.48
Purity	99.92%
Formula	C₂₀H₂₄N₂OS
SMILES	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12
Target	DNA/RNA Synthesis,Parasite,Autophagy
Solubility	DMSO:60 mg/mL (176.22 mM)

Bioactivity

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In Vitro

Lucanthone, an innovative autophagy inhibitor, induces apoptosis through cathepsin D activation and has been evaluated for its anticancer efficacy via MTT assay. Demonstrating a consistent reduction in viability across seven breast cancer cell lines, Lucanthone surpasses Chloroquine (CQ) in potency, evidenced by a significantly lower mean IC50 of 7.2 μM compared to 66 μM for CQ. Further validation through ATPlite assay and trypan blue exclusion in two representative cell lines (MDA-MB-231 and BT-20) confirms these findings.

Cell Research

Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, Lucanthone, Lucanthonum, Lucantona, inhibit, Autophagy, APE1, DNA Synthesis, DNASynthesis, RNASynthesis, RNA Synthesis

Quality Guarantee

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Compound Identifiers

PubChem CID

10180 ↗

Key Properties

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No computed properties available.

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Lucanthone (orb1302749)

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CAS Number:	64345-84-2
MW:	452.59
Formula:	C₂₁H₂₈N₂O₅S₂

CAS Number:	5615-06-5
MW:	356.48
Formula:	C₂₀H₂₄N₂O₂S

Purity:	98.78% (May vary between batches)
CAS Number:	3105-97-3
MW:	356.48
Formula:	C₂₀H₂₄N₂O₂S

CAS Number:	548-57-2
MW:	376.94
Formula:	C₂₀H₂₅ClN₂OS

Purity:	>98% (HPLC)
CAS Number:	479-50-5
MW:	340.48
Formula:	C₂₀H₂₄N₂OS

Lucanthone

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Lucanthone (orb1302749)

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