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Masoprocol

SKU: orb1689335

Description

Masoprocol (meso-Nordihydroguaiaretic acid) is a natural lipoxygenase (LOX) inhibitor derived from the creosote bush, Larrea tridentata. It exhibits anticancer and antihyperglycemic properties, supporting its research application in type 2 diabetes studies involving both in vitro enzymatic assays and in vivo metabolic models.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number27686-84-6
MW302.37
Purity99.76%
FormulaC18H22O4
SMILESC([C@@H]([C@@H](CC1=CC(O)=C(O)C=C1)C)C)C2=CC(O)=C(O)C=C2
TargetLipoxygenase
SolubilityDMSO:80 mg/mL (264.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.91 mM)

Bioactivity

In Vivo
METHODS: Masoprocol (10-80 mg/kg, orally, twice daily for 4-8 days) was administered to rats fed fructose to determine whether Masoprocol could also reduce TG concentrations in rats with fructose-induced hypertriglyceridemia (HTG). RESULTS: Masoprocol administration to rats with fructose-induced HTG resulted in a decrease in serum TG levels, a decrease in hepatic TG secretion, and an increase in peripheral TG clearance.
In Vitro
Masoprocol (30 μM; 90 min) treatment of adipocytes showed elevated basal and insulin-stimulated glucose clearance in adipocytes .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

meso-NDGA, meso-Nordihydroguaiaretic acid, LOX

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Key Properties

No computed properties available.

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Protocol Information

Masoprocol (orb1689335)

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% DMSO +
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% Tween 80 +
%

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2 mg
$ 140.00
DispatchUsually dispatched within 5-10 working days
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