MCHR1 antagonist 2

SKU: orb1309443

Description

MCHR1 antagonist 2

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	863115-70-2
MW	424.42
Purity	98.29%
Formula	C₂₃H₂₁FN₂O₅
SMILES	Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1
Target	GPCR,Potassium Channel,Melanin-concentrating Hormone Receptor (MCHR)
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.36 mM);DMSO:9 mg/mL (21.21 mM)

Bioactivity

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Target IC50	ERG (human):4.0 nM(IMR-32 cells)\|MCH1R:65 nM \|Ca2+ flux:196 ± 30 nM((IMR-32 cells))
In Vitro	MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells.MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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concentrating, KcsA, IMR-32, inhibit, Inhibitor, hERG in IMR-32 cells, hERG, hormone, MelaninconcentratingHormoneReceptor(MCHR), MelaninconcentratingHormoneReceptor, Melaninconcentrating Hormone Receptor (MCHR), melanin, Melanin concentrating hormone receptor 1, melanin concentrating hormone receptor 1, Melanin-concentrating Hormone Receptor, MCHR, MCHR1 (GPR24), MCHR1 antagonist 2, MCHR-1 antagonist 2, MCH1-R, Potassium Channel

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Compound Identifiers

PubChem CID

11464405 ↗

Key Properties

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No computed properties available.

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