Metoclopramide hydrochloride

SKU: orb1224145

Description

Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.(In Vitro):Metoclopramide (0.01-10 μM) hydrochloride hydrate stimulates aldosterone release in isolated perfused rat zona glomerulosa cells.Metoclopramide hydrochloride hydrate results in prokinesis by four mechanisms: inhibition of presynaptic D2 receptors and stimulation of presynaptic excitatory 5-HT4 receptors, thereby allowing acetylcholine (ACh) release from intrinsic cholinergic motor neurons; inhibition of D2 postsynaptic receptors; and antagonism of the presynaptic inhibition of muscarinic receptors, leading to further augmentation of ACh release.(In Vivo):Metoclopramide (6.7 μg/g; s.c. daily for 50 days) hydrochloride hydrate significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle.Metoclopramide (5-40 mg/kg; i.p.) hydrochloride hydrate induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice.Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride hydrate induces stereotyped cage climbing behaviour in mice.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	7232-21-5
MW	336.26
Purity	>98% (HPLC)
Formula	C₁₄H₂₂ClN₃O₂·HCl
SMILES	Cl.CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC
Target	5-HT Receptor
Solubility	Ethanol: 67 mg/mL (199.25 mM); Water: 67 mg/mL (199.25 mM); DMSO: 67 mg/mL warmed (199.25 mM)

Bioactivity

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In Vivo

Metoclopramide (6.7 μg/g; s. c. daily for 50 days) hydrochloride significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle. Metoclopramide (5-40 mg/kg; i.p.) hydrochloride induces catalepsy and antagonizes Apomorphine induced cage climbing behaviour in mice. Metoclopramide (1.25-2.5 mg/kg; i.p.) hydrochloride induces stereotyped cage climbing behaviour in mice. Animal model: Adult, virgin female mice of the Swiss EPM-1 strain. Dosage: 6.7 μg/g. Administration: S. c. daily for 50 days. Result: Increased the number but also stimulated the metabolic activity of lactotrophs.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NSC 354467

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Gene Symbol

5-HT Receptor

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