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Metoprine

SKU: orb1298843

Description

Metoprine

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number7761-45-7
MW269.13
Purity99.09%
FormulaC11H10Cl2N4
SMILESCC=1C(=C(N)N=C(N)N1)C2=CC(Cl)=C(Cl)C=C2
TargetAntifolate,Histone Methyltransferase,Histamine Receptor
SolubilityDMSO:4 mg/mL (14.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.72 mM)

Bioactivity

In Vivo
In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain. Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

diaminopyrimidine, BW 197U, barrier, blood-brain, antitumor, antifolate, Antifolate, HistamineReceptor, Histamine Receptor, histamine, histamine N-methyl transferase, Histone Methyltransferase, HistoneMethyltransferase, HMT, Inhibitor, inhibit, N-methyltransferase, Metoprine

Similar Products

  • Metoprine [orb1219949]

    >98% (HPLC)

    7761-45-7

    269.13

    C11H10Cl2N4

    1 g, 500 mg, 10 mg, 50 mg, 100 mg, 25 mg, 5 mg
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Key Properties

No computed properties available.

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Metoprine (orb1298843)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

5 mg
$ 100.00
10 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
25 mg
$ 200.00
50 mg
$ 310.00
100 mg
$ 440.00
500 mg
$ 960.00
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