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ML346

SKU: orb1304019

Description

ML346 is a small molecule activator of the Hsp70 chaperone protein. It is used in research to study protein folding, neurodegenerative diseases, and cancer mechanisms in both cellular and animal models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number100872-83-1
MW272.26
Purity99.36% (May vary between batches)
FormulaC14H12N2O4
SMILESCOc1ccc(\C=C\C=C2C(=O)NC(=O)NC2=O)cc1
TargetHSP
SolubilityDMSO:11 mg/mL (40.4 mM);10% DMSO+90% Saline:1 mg/mL (3.67 mM)

Bioactivity

Target IC50
HSP70:4.6 μM (EC50, HeLa cells)
In Vivo
ML346 activates transcription of the Hsp70 promoter and suppresses aggregation of poly-glutamines in a C. elegans model, suggesting the probe has efficacy in modifying protein aggregation and associated toxicity. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models.
In Vitro
ML346 has good chemical stability, significantly high water solubility, is not reactive with excess glutathione, and is cell permeable. The probe ML346 will help elucidate roles for activation of Hsp70 and HSF-1 in the prevention and progression of cancers, cellular aging, and metabolic and neurodegenerative disorders. ML346 is a novel modulator of proteostasis for protein conformational diseases.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

HSP70, HSP, Heat shock proteins, heat, Inhibitor, inhibit, ML 346, ML346, ML-346, cytotoxicity, conformational, chaperones, response, shock, probe, protein

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Quality Guarantee

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

ML346 (orb1304019)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 160.00
25 mg
$ 220.00
50 mg
$ 330.00
100 mg
$ 490.00
500 mg
$ 1,030.00
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