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ML351

SKU: orb1217600

Description

ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).

Images & Validation

Key Properties

CAS Number847163-28-4
MW249.27
Purity>98% (HPLC)
FormulaC15H11N3O
SMILESCNC1=C(N=C(O1)C2=CC=CC3=CC=CC=C32)C#N
TargetLipoxygenase
SolubilityDMSO:10 mM

Bioactivity

In Vivo
Animal model: Nine-week-old male C57BL/6J mice. Dosage: 0 mg/kg; 24 mg/kg; 48 mg/kg. Administration: Intraperitoneal injection before the beginning of the STZ series and concluding 5 days after the last dose of STZ. Result: Protected against diabetes development in an STZ β-cell injury model that mimics the inflammation seen in T1D. Animal model: Female NOD mice develop spontaneous autoimmune diabetes between 12 and 24 weeks of age. Dosage: 0 mg/kg; 24 mg/kg; 48 mg/kg. Administration: Intraperitoneal injection before the beginning of the STZ series and concluding 5 days after the last dose of STZ. Result: Protected Against Early Glycemic Deterioration in NOD Mice.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • ML351 [orb1306158]

    97.86% (May vary between batches)

    847163-28-4

    249.27

    C15H11N3O

    100 mg, 1 ml x 10 mM (in DMSO), 25 mg, 50 mg, 5 mg, 10 mg, 1 mg
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ML351 (orb1217600)

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Available Sizes

Select a size below

2 mg
$ 140.00
5 mg
$ 190.00
10 mg
$ 300.00
25 mg
$ 600.00
50 mg
$ 870.00
100 mg
$ 1,230.00
500 mg
$ 2,440.00